Iqela elivela kwiZiko lokuchuma leYunivesithi yase-Columbia liphumelele ukukhulelwa kokuqala ngokusebenzisa inkqubo yobukrelekrele bokwenziwa Yenzelwe ukubuyisela isidoda kwiimeko ze-azoospermia, imeko apho amadlozi abonisa ukuba akukho ziseli ezibonakalayo zokuzala. Isiganeko esibalulekileyo, esichazwe kwileta yophando kwiLancet, simele inyathelo elibalulekileyo eliya phambili iyeza lokuzala kwi ukucwangcisa ukukhulelwa nasekulungiseni ukungazali kwamadoda.
Kulo mxholo, izinto zamadoda zikhoyo malunga I-40% yeemeko zokungazaliKwaye phakathi kwe-10% kunye ne-15% yamadoda angenanzala ane-azoospermia. Nangona isampulu isenokubonakala iqhelekile, ujongo olusondeleyo ludla ngokubonisa ukuba akukho madlozi abonakalayo; njengoko umlawuli weziko, uZev Williams, eshwankathela, abaninzi izibini ezicwangcisa ukukhulelwa kwazo Baxelelwa ukuba ukhetho lwabo lwebhayoloji lulinganiselwe kakhulu, into enokuthi le nkqubela phambili inokwenzeka cinga kwakhona.
Indlela STAR isebenza ngayo
Ukujongana nalo mngeni, iqela liphuhlise i-STAR (Sperm Tracking and Recovery), inkqubo edibanisa umbono wekhompyuter, i-microfluidics, kunye neerobhothi ezichanekileyo ukuchonga nokuhlangula isidoda esinqabileyo kakhulu ngaphandle kokuwonakalisa.
Inkqubo ibamba izigidi zemifanekiso echanekileyo yesampuli ngexesha elifutshane; I-AI ibona i-sperm enokubakho, itshiphu enemijelo ye-microfluidic ilawula inxalenye yomdla, kwaye kumcimbi milliseconds, irobhothi Ikhupha ngobunono iseli ekhethiweyo ukuba isetyenziswe kwi-in vitro fertilization okanye i-cryopreservation.
Ityala elavuselela ithemba
Indlela yavavanywa kwisigulane eso iqabane laso linxibe isixhobo sokuthintela ukukhulelwa. phantse amashumi amabini eminyaka ndizama ukuba nabantwana, emva kwemijikelo ye-IVF engaphumelelanga kunye notyando olubini olungaphumelelanga lokususa amasende. Kude kube ngoko, iindlela ezizezinye zazingqineke zingasebenzi kwaye zineziphumo ebezingalindelekanga.
Ukusuka kwisampuli ye-3,5 milliliters, i-STAR ihlalutye malunga Imifanekiso ye-2,5 yezigidi malunga neeyure ezimbini kwaye yafumana amadlozi amabini asebenzayo. Ezi seli zimbini zasetyenziselwa ukuvelisa iimbumba ezimbini, kwaye enye yazo ibangele a ukukhulelwa okuqhubekayo, ukukhumbula umgaqo wekliniki ukuba iseli enye enempilo yanele ukuqalisa uphuhliso lwe-embryonic.
Yintoni etshintshayo kukungazali
Amanani abeka le ngxaki ngokwembono: into eyindoda ibandakanyeka kwi-40% yamatyala obudlolo, kwaye phakathi kwezo, I-Azoospermia ikhona kwi-10% -15% yamadoda ngobunzima bokuzala. Ukuza kuthi ga ngoku, izigulane ezininzi zixhomekeke ekususweni ngokuthe ngqo kwi-testicle okanye ukukhangela okwenziwa ngesandla kwilabhoratri.
Zombini iindlela zinemida: iinkqubo zotyando zi Ingenile Bahlala behluleka ukubuyisela iiseli ezisebenzayo, kunye neengozi ezifana nokuvuvukala, ukuguqulwa kwe-vascular, okanye ukuncipha kwexeshana kwi-testosterone; Ngeli xesha, ukuskena ngesandla kubandakanya amaxesha amade, iindleko eziphezulu, kunye nokukhohlisa okunokuthi ukusebenza kakuhle yedlozi.
Indlela ezenzekelayo ye-STAR ilungisa le miqobo ngokudibanisa ukufunyanwa ngokukhawuleza kunye nokwahlukaniswa okuchanekileyo, okunokunciphisa ukusetyenziswa kweendlela ezinobundlobongela kunye nokwandisa amathuba okufumana oko. amadlozi esitshixo xa inani labo liphantsi kakhulu.
Amanyathelo alandelayo kunye neziphumo ezinokwenzeka eYurophu
Nangona oku kuyimeko yokuqala, iqela laseColumbia libonisa ukuba bayaqhubeka izilingo ezinkulu zeklinikhi ukuvavanya ukusebenza kunye nokuveliswa kwakhona kwendlela kubantu abahlukeneyo. Le nkqubo iya kubaluleka ekuvavanyeni ukubandakanywa kwayo okuqhubekayo njengesixhobo esisemgangathweni kwi iiklinikhi zokuchuma.
Ukuba ukusebenza kwayo kuqinisekisiwe, amaziko aseYurophu naseSpain anokuba nomdla wokudibanisa izisombululo ezifanayo, into eya kufuna ubungqina obuqinileyo, ukuqinisekiswa kobugcisa kunye nokuthotyelwa kweenkqubo eziqhelekileyo zokulawula European UnionUkuthathwa komntwana ongamzalanga abe ngowakho kuya kubandakanya ukungqinisisa iziphumo, ukuchaza iindlela zokusetyenziswa, kunye nokuqinisekisa ukuba itekhnoloji isetyenziselwa ukunceda isigulana kunye iziqinisekiso zomgangatho.
Le nkqubela ayisusi yonke imiqobo ngexesha elinye, kodwa ivula indlela ebonakalayo: inkqubo ene I-AI iyakwazi ukufumana into ebingabonwa ngaphambiliesele ikhokelele ekukhulelweni kwaye, ukuba izifundo ziyayixhasa, inokutshintsha indlela ye-azoospermia ekuncediseni ukubonisana nokuzala.
